The work of the Fraunhofer IVV, Dresden focuses on the efficient design of processing and cleaning operations for the food, pharmaceutical, and packaging industries. For our R&D work on the processing flexible materials and wet-chemical and dry cleaning we use process analyses and simulations to develop adaptive mechatronic, thermotronic, and fluid mechanical systems for existing processes and Industry 4.0 concepts. This development work is facilitated by new measuring and test methods for quality parameters and material processing behavior. Modern methods of data analysis are used to determine weaknesses and opportunities for improving industrial processes. Assistance systems provide innovative approaches for human-machine interaction.